腈水解化学合成酸

was poured into a separatory funnel and extracted with diethyl ether (3 × 50 mL). The combined organic extracts were washed with water (60 mL) and dried over sodium sulfate (25 g). After filtration, the solvent was removed by rotary evaporation, and the yellow liquid residue was

distilled under reduced pressure to afford 2-phenylpropionic acid (14.3 g, 93%) as a pale-yellow liquid.

Reference: Organic Syntheses Coll. Vol. 10, 640

3 、亚硝衍生物钠有利于的吡啶的衍生物里面脱水下例

A mixture of compound 1 (6.6 g, 35 mmol), conc. H2SO4 (29 ml), AcOH ( 58 ml) and water (115 ml) was heated at 120°C for 1h, then a solution of NaNO2 (4.0 g), in water (30 ml) was added at 90~100°C. After the mixture had been heated for 1 h, NaCl (40 g) was added to the hot mixture and the whole was cooled in an ice-bath. The precipitate was collected to give the crude free acid (6.2 g, 62%).

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吡啶在硫衍生物/甲醇里面加热转回可以并不需要得到相应的衍生物。

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